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| Febuxostat |
Febuxostat is used for:
Long-term treatment of high blood uric acid levels in patients with gout.
Febuxostat is a xanthine oxidase inhibitor. It works by blocking an enzyme in the body (xanthine oxidase), which lowers levels of uric acid in the blood. This helps to prevent gout flare-ups.
Do NOT use febuxostat if:
you are allergic to any ingredient in febuxostat
you do not have symptoms caused by high blood uric acid levels
you have high blood uric acid levels caused by a condition other than gout (eg, Lesch-Nyhan syndrome, cancer or treatment of cancer, organ transplant)
you are taking azathioprine, didanosine, or mercaptopurine
Contact your doctor or health care provider right away if any of these apply to you.
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Out With Gout - Everything You Need To Know About Gout
Before using febuxostat:
Some medical conditions may interact with febuxostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver or kidney problems
if you have a history of heart problems (eg, a heart attack) or a stroke
Some MEDICINES MAY INTERACT with febuxostat. Tell your health care provider if you are taking any other medicines, especially any of the following:
Azathioprine, didanosine, mercaptopurine , and theophylline because the risk of their side effects may be increased by febuxostat
This may not be a complete list of all interactions that may occur. Ask your health care provider if febuxostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.How to use febuxostat:
Use febuxostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with febuxostat. Talk to your pharmacist if you have questions about this information.
Take febuxostat by mouth with or without food.
Continue to take febuxostat even if you feel well. Do not miss any doses.
If you miss a dose of febuxostat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use febuxostat.
Important safety information:
Some patients may experience a gout flare-up when they start taking febuxostat. Your doctor may prescribe a nonsteroidal anti-inflammatory drug (NSAID) or colchicine to take to help control or prevent a gout flare-up. If you experience a gout flare-up, do not stop taking febuxostat without talking to your doctor. Talk with your doctor if you have any questions or concerns.
Lab tests, including uric acid levels and liver function, may be performed while you take febuxostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Febuxostat should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking febuxostat while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take febuxostat, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of febuxostat:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:Febuxostat is used to lower uric acid levels in people with gout. Febuxostat works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout.Febuxostat is a non-hygroscopic, white crystalline powder that is freely soluble in dimethylformamide; soluble in dimethylsulfoxide; sparingly soluble in ethanol; slightly soluble in methanol and acetonitrile; and practically insoluble in water. The melting range is 205°C to 208°C.
ULORIC tablets for oral use contain the active ingredient, febuxostat, and are available in two dosage strengths, 40 mg and 80 mg. Inactive ingredients include lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, sodium croscarmellose, silicon dioxide and magnesium stearate. ULORIC tablets are coated with Opadry II, green.
Long-term treatment of high blood uric acid levels in patients with gout.
Febuxostat is a xanthine oxidase inhibitor. It works by blocking an enzyme in the body (xanthine oxidase), which lowers levels of uric acid in the blood. This helps to prevent gout flare-ups.
Do NOT use febuxostat if:
you are allergic to any ingredient in febuxostat
you do not have symptoms caused by high blood uric acid levels
you have high blood uric acid levels caused by a condition other than gout (eg, Lesch-Nyhan syndrome, cancer or treatment of cancer, organ transplant)
you are taking azathioprine, didanosine, or mercaptopurine
Contact your doctor or health care provider right away if any of these apply to you.
Advertisement
Slideshow
Out With Gout - Everything You Need To Know About Gout
Before using febuxostat:
Some medical conditions may interact with febuxostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver or kidney problems
if you have a history of heart problems (eg, a heart attack) or a stroke
Some MEDICINES MAY INTERACT with febuxostat. Tell your health care provider if you are taking any other medicines, especially any of the following:
Azathioprine, didanosine, mercaptopurine , and theophylline because the risk of their side effects may be increased by febuxostat
This may not be a complete list of all interactions that may occur. Ask your health care provider if febuxostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.How to use febuxostat:
Use febuxostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with febuxostat. Talk to your pharmacist if you have questions about this information.
Take febuxostat by mouth with or without food.
Continue to take febuxostat even if you feel well. Do not miss any doses.
If you miss a dose of febuxostat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use febuxostat.
Important safety information:
Some patients may experience a gout flare-up when they start taking febuxostat. Your doctor may prescribe a nonsteroidal anti-inflammatory drug (NSAID) or colchicine to take to help control or prevent a gout flare-up. If you experience a gout flare-up, do not stop taking febuxostat without talking to your doctor. Talk with your doctor if you have any questions or concerns.
Lab tests, including uric acid levels and liver function, may be performed while you take febuxostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Febuxostat should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking febuxostat while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take febuxostat, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of febuxostat:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:Febuxostat is used to lower uric acid levels in people with gout. Febuxostat works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout.Febuxostat is a non-hygroscopic, white crystalline powder that is freely soluble in dimethylformamide; soluble in dimethylsulfoxide; sparingly soluble in ethanol; slightly soluble in methanol and acetonitrile; and practically insoluble in water. The melting range is 205°C to 208°C.
ULORIC tablets for oral use contain the active ingredient, febuxostat, and are available in two dosage strengths, 40 mg and 80 mg. Inactive ingredients include lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, sodium croscarmellose, silicon dioxide and magnesium stearate. ULORIC tablets are coated with Opadry II, green.
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